将带有线条的自定义元素添加到 ggplot 对象?

Add a custom element with lines to a ggplot object?

我使用 ggplot2 绘制了 Kaplan Meier 图,表示 3 组患者之间的无病生存率(以 % 为单位):未暴露于风险因素的患者 (No exposure),暴露于风险因素 1 (Exposure 1) 或暴露于风险因素 2 (Exposure 2) 的人。数据和图表如下所示:

# Load packages
library(tidyverse)
library(magrittr)

# Get data.
data <- 
structure(list(time = c(15.4661190965092, 14.2340862422998, 14.8501026694045, 
9.94934976043806, 4.5119780971937, 7.76454483230664, 12.3121149897331, 
11.7344284736482, 15.6030116358658, 11.9123887748118, 13.9493497604381, 
3.09377138945927, 9.97672826830938, 6.24229979466119, 11.0362765229295, 
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14.2614647501711, 1.95208761122519, 13.3744010951403, 10.4804928131417, 
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7.61396303901437, 0.939082819986311, 7.0362765229295, 12.911704312115, 
16.0574948665298, 5.34702258726899, 13.3032169746749, 5.637234770705, 
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6.07802874743327, 15.2142368240931, 11.8001368925394, 2.92676249144422, 
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4.36960985626283, 12.7775496235455, 15.0280629705681, 13.8891170431211, 
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"Exposure 3", "Exposure 1", "Exposure 2", "Exposure 2", "Exposure 3", 
"Exposure 1", "Exposure 1", "Exposure 3", "Exposure 2", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 3", "Exposure 2", "Exposure 3", 
"Exposure 3", "Exposure 3", "Exposure 3", "Exposure 1", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 1", "Exposure 1", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 3", "Exposure 2", "Exposure 1", 
"Exposure 1", "Exposure 2", "Exposure 1", "Exposure 2", "Exposure 1", 
"Exposure 3", "Exposure 2", "Exposure 1", "Exposure 1", "Exposure 1", 
"Exposure 3", "Exposure 2", "Exposure 3", "Exposure 1", "Exposure 1", 
"Exposure 1", "Exposure 2", "Exposure 2", "Exposure 2", "Exposure 2", 
"Exposure 1", "Exposure 3", "Exposure 1", "Exposure 2", "Exposure 1", 
"Exposure 2", "Exposure 1", "Exposure 1", "Exposure 2", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 3", "Exposure 3", "Exposure 1", 
"Exposure 3", "Exposure 2", "Exposure 1", "Exposure 3", "Exposure 1", 
"Exposure 3", "Exposure 3", "Exposure 1", "Exposure 3", "Exposure 1", 
"Exposure 2", "Exposure 3", "Exposure 3", "Exposure 2", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 1", "Exposure 3", "Exposure 2", 
"Exposure 2", "Exposure 3", "Exposure 1", "Exposure 2", "Exposure 3", 
"Exposure 3", "Exposure 1", "Exposure 1", "Exposure 2", "Exposure 2", 
"Exposure 3", "Exposure 3", "Exposure 2", "Exposure 3", "Exposure 3", 
"Exposure 2", "Exposure 1", "Exposure 1", "Exposure 2", "Exposure 3", 
"Exposure 1", "Exposure 1", "Exposure 1", "Exposure 1", "Exposure 3", 
"Exposure 1", "Exposure 1", "Exposure 1", "Exposure 2", "Exposure 1", 
"Exposure 3", "Exposure 2", "Exposure 1", "Exposure 3", "Exposure 1", 
"Exposure 2", "Exposure 3", "Exposure 1", "Exposure 2", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 2", "Exposure 1", "Exposure 1", 
"Exposure 2", "Exposure 2", "Exposure 3", "Exposure 3", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 3", "Exposure 3", "Exposure 1", 
"Exposure 1", "Exposure 1", "Exposure 1", "Exposure 2", "Exposure 2", 
"Exposure 1", "Exposure 3", "Exposure 1", "Exposure 3")), class = "data.frame", row.names = c(NA, 
-200L))

# Make the plot:
data %>% 
  ggplot(aes(x=time, y=surv)) + 
  geom_line(aes(color=group), size=0.3) + 
  scale_y_continuous(name="Disease-free survival (%)") +
  scale_x_continuous(name="Follow-up time (years)") +
  scale_color_manual(name="Groups", 
                     values=c("Exposure 1"="firebrick3", "Exposure 2"="#255B1D", "Exposure 3"="darkblue"), 
                     labels=c("Exposure 1 (p<.01)", "Exposure 2 (p=.02)", "Exposure 3 (p=.03)")) + 
  theme_classic() + 
  theme(legend.position=c(0.3, 0.3))

这会产生以下情节:

在此图中,p 值表示每组与未暴露组之间的生存差异(使用对数秩检验)。现在我还比较了两个暴露组 Exposure 1Exposure 2 之间的生存率,其 p 值为 p=.01。我想通过以下方式将其添加到情节中:

我已经在 Paint 中完成了这个(非常丑陋的)改编,但我希望能够在 R 中完成。有帮助吗?

也许最简单的方法是绘制您自己的图例,这样您就无需猜测将线条放在哪里,并且在绘图调整大小时相对位置保持不变:

data %>% 
  ggplot(aes(x=time, y=surv)) + 
  geom_line(aes(color=group), size=0.3) + 
  scale_y_continuous(name = "Disease-free survival (%)") +
  scale_x_continuous(name = "Follow-up time (years)") +
  scale_color_manual(name = "Groups", 
                     values=c("firebrick3", "#255B1D", "darkblue")) +
  geom_line(data = data.frame(time = c(3.9, 5, 3.9, 5, 3.9, 5),
                              surv = c(84, 84, 83, 83, 82, 82),
                              group = rep(paste('Exposure', 1:3), each = 2)),
            aes(color = group)) +
  geom_text(data = data.frame(time = c(5.3, 5.3, 5.3, 10), 
                              surv = c(84, 83, 82, 82.5),
                              group = c("No Exposure", "Exposure 1 (p = 0.02)",
                                        "Exposure 2 (p = 0.03)", "p = 0.01")),
            aes(label = group), hjust = 0, size = 3.2) +
  geom_path(data = data.frame(time = c(9, 9.5, 9.5, 9), 
                              surv = c(82, 82, 83, 83))) +
  annotate('text', x = 3.8, y = 85.2, label = "Groups", hjust = 0, size = 4) +
  theme_classic() + 
  theme(legend.position = 'none')